人类免疫缺陷病毒脑炎和进行性多灶性白质脑病的磁化传递研究。阿基坦地区艾滋病临床流行病学研究小组。
Magnetization transfer study of HIV encephalitis and progressive multifocal leukoencephalopathy. Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.
作者信息
Dousset V, Armand J P, Lacoste D, Mièze S, Letenneur L, Dartigues J F, Caill J M
机构信息
Service de Neuroradiologie, Hopital Pellegrin-Tripode, CHU de Bordeaux, France.
出版信息
AJNR Am J Neuroradiol. 1997 May;18(5):895-901.
PURPOSE
To ascertain whether the use of magnetization transfer (MT) in MR imaging can characterize tissue destruction in human immunodeficiency virus (HIV)-positive patients with presumed progressive multifocal leukoencephalopathy (PML) or HIV encephalitis.
METHODS
Brain MR studies that included MT were obtained in three groups: 11 healthy control subjects, 10 HIV-positive patients with clinical and radiologic findings of PML, and 13 HIV-positive patients with HIV encephalitis. MT ratios (MTRs) were calculated in PML and HIV encephalitis lesions and in normal-appearing white matter in the patients and control subjects.
RESULTS
PML lesions revealed a dramatic decrease in MTR (22% +/- 2.3). HIV encephalitis lesions had statistically significantly higher MTR values (40% +/- 3.8) than PML lesions. The MTR of normal-appearing white matter was significantly higher in the control subjects (47% +/- 2.3) than in the PML group (46% +/- 3.3) or the HIV encephalitis group (44% +/- 2.6).
CONCLUSION
MTR determinations suggest the possibility of distinguishing PML from HIV encephalitis and of indicating whether HIV encephalitis is involved in white matter that appears normal on conventional MR images.
目的
确定磁共振成像（MR）中磁化传递（MT）的应用是否能够对疑似进行性多灶性白质脑病（PML）或HIV脑炎的人类免疫缺陷病毒（HIV）阳性患者的组织破坏进行特征描述。
方法
对三组对象进行了包含MT的脑部MR研究：11名健康对照者、10名有PML临床及影像学表现的HIV阳性患者以及13名患有HIV脑炎的HIV阳性患者。计算了患者及对照者PML和HIV脑炎病灶以及正常白质区域的MT比率（MTR）。
结果
PML病灶的MTR显著降低（22%±2.3）。HIV脑炎病灶的MTR值（40%±3.8）在统计学上显著高于PML病灶。对照者正常白质区域的MTR（47%±2.3）显著高于PML组（46%±3.3）或HIV脑炎组（44%±2.6）。
结论
MTR测定提示有可能区分PML与HIV脑炎，并提示HIV脑炎是否累及常规MR图像上看似正常的白质。
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