Kim J Y, Choi Y S, Lee J H
Department of Ophthalmology, Seoul National University Hospital, Korea.
J Cataract Refract Surg. 1997 Apr;23(3):447-9. doi: 10.1016/s0886-3350(97)80192-7.
After having photorefractive keratectomy (PRK), a 29-year-old man suffered from delayed epithelial healing and corneal stromal ring infiltrates. All laboratory results including smear, culture, and biopsy for bacteria, herpes simplex virus, and Acanthamoeba were negative. The suspected cause was patient abuse of anesthetics. Subsequently, it was discovered that for 6 months, since just after the PRK, the patient had intermittently used topical proparacaine drops. After all medication was discontinued and the eye pressure patched, the corneal epithelium healed completely. Practitioners should consider the possibility of topical anesthetic abuse in cases of keratitis after PRK.
一名29岁男性在接受准分子激光角膜切削术（PRK）后，出现上皮愈合延迟和角膜基质环浸润。所有实验室检查结果，包括细菌、单纯疱疹病毒和棘阿米巴的涂片、培养及活检均为阴性。怀疑病因是患者滥用麻醉剂。随后发现，自PRK术后起的6个月里，该患者间歇性使用局部丙美卡因滴眼液。停用所有药物并对眼睛进行包扎后，角膜上皮完全愈合。从业者在PRK术后发生角膜炎的病例中应考虑局部麻醉剂滥用的可能性。
