Fossey M D, Hamner M B
Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29401, USA.
Anxiety. 1994;1(5):233-6.
Medication-induced sexual dysfunction can significantly interfere with patients' quality of life and lead to poor compliance. This retrospective study examined the records of 100 male veterans with post-traumatic stress disorder (PTSD) selected in alphabetical order from an active treatment file of 230 patients. Forty-two patients had received clonazepam (mean maximum dose: 3.4 +/- 1.6 mg/day) at some point during their treatment. Of these, 18 (42.9%) complained of significant sexual dysfunction (primarily erectile dysfunction). Eighty-four patients received diazepam (mean maximum dose: 52.1 +/- 29.7 mg/day), nine received alprazolam (mean maximum dose: 5.2 +/- 2.8 mg/day) and eight received lorazepam (mean maximum dose: 3.8 +/- 2.4 mg/day). None of these patients complained of sexual dysfunction during treatment with these three other benzodiazepines. Our findings suggest that benzodiazepines, particularly clonazepam in the current study, can be a cause of sexual dysfunction in many male patients. Prospective studies comparing the overall clinical utility of various benzodiazepines are indicated in this and other clinic populations.
药物引起的性功能障碍会严重干扰患者的生活质量并导致依从性差。这项回顾性研究检查了从230名患者的现行治疗档案中按字母顺序挑选出的100名患有创伤后应激障碍（PTSD）的男性退伍军人的记录。42名患者在治疗期间的某个时间点接受过氯硝西泮（平均最大剂量：3.4±1.6毫克/天）。其中，18名（42.9%）抱怨有明显的性功能障碍（主要是勃起功能障碍）。84名患者接受过地西泮（平均最大剂量：52.1±29.7毫克/天），9名接受过阿普唑仑（平均最大剂量：5.2±2.8毫克/天），8名接受过劳拉西泮（平均最大剂量：3.8±2.4毫克/天）。在用这三种其他苯二氮䓬类药物治疗期间，这些患者均未抱怨性功能障碍。我们的研究结果表明，苯二氮䓬类药物，尤其是本研究中的氯硝西泮，可能是许多男性患者性功能障碍的一个原因。对于此类及其他临床人群，需要进行前瞻性研究以比较各种苯二氮䓬类药物的总体临床效用。
