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Use of nonpeptide antagonists to explore the physiological roles of neurotensin. Focus on brain neurotensin/dopamine interactions.

作者信息

Rostene W, Azzi M, Boudin H, Lepee I, Souaze F, Mendez-Ubach M, Betancur C, Gully D

机构信息

INSERM U.339, Hôpital St. Antoine, Paris, France.

出版信息

Ann N Y Acad Sci. 1997 Apr 24;814:125-41. doi: 10.1111/j.1749-6632.1997.tb46151.x.

DOI:10.1111/j.1749-6632.1997.tb46151.x
PMID:9160965
Abstract
摘要

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Use of nonpeptide antagonists to explore the physiological roles of neurotensin. Focus on brain neurotensin/dopamine interactions.使用非肽拮抗剂探索神经降压素的生理作用。聚焦于脑内神经降压素/多巴胺相互作用。
Ann N Y Acad Sci. 1997 Apr 24;814:125-41. doi: 10.1111/j.1749-6632.1997.tb46151.x.
2
Anatomy and mechanisms of neurotensin-dopamine interactions in the central nervous system.中枢神经系统中神经降压素-多巴胺相互作用的解剖学及机制
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Regulation of the neurotensin NT(1) receptor in the developing rat brain following chronic treatment with the antagonist SR 48692.慢性给予拮抗剂SR 48692后发育中大鼠脑内神经降压素NT(1)受体的调节
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Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy.内源性神经降压素可减弱多巴胺依赖性运动和刻板行为。
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The non-peptide neurotensin receptor antagonist SR48692 is not a potent antagonist of neurotensin(8-13) responses of rat substantia nigra neurones in vitro.非肽类神经降压素受体拮抗剂SR48692并非大鼠黑质神经元体外神经降压素(8-13)反应的强效拮抗剂。
Neurosci Lett. 1994 May 19;172(1-2):175-8. doi: 10.1016/0304-3940(94)90690-4.
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Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692.非肽类神经降压素受体拮抗剂SR48692对神经降压素诱导的胰腺癌生长的抑制作用
Cancer. 1997 May 1;79(9):1787-93. doi: 10.1002/(sici)1097-0142(19970501)79:9<1787::aid-cncr22>3.0.co;2-t.
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Effects of SR 48692, a selective non-peptide neurotensin receptor antagonist, on two dopamine-dependent behavioural responses in mice and rats.选择性非肽类神经降压素受体拮抗剂SR 48692对小鼠和大鼠两种多巴胺依赖性行为反应的影响。
Psychopharmacology (Berl). 1994 Oct;116(2):237-41. doi: 10.1007/BF02245067.
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Increase in neurotensin receptor expression in rat brain induced by chronic treatment with the nonpeptide neurotensin receptor antagonist SR 48692.非肽类神经降压素受体拮抗剂SR 48692长期处理诱导大鼠脑内神经降压素受体表达增加。
Neurosci Lett. 1994 May 19;172(1-2):97-100. doi: 10.1016/0304-3940(94)90671-8.
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Turning behavior induced by intrastriatal injection of neurotensin in mice: sensitivity to non-peptide neurotensin antagonists.纹状体内注射神经降压素诱导小鼠的转向行为:对非肽类神经降压素拮抗剂的敏感性
Naunyn Schmiedebergs Arch Pharmacol. 1994 Jan;349(1):57-60. doi: 10.1007/BF00178206.
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The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes.非肽类神经降压素拮抗剂SR 48692,用作揭示假定神经降压素受体亚型的工具。
Br J Pharmacol. 1994 Jun;112(2):352-4. doi: 10.1111/j.1476-5381.1994.tb13077.x.

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Neurotensin receptor1 antagonist SR48692 reduces proliferation by inducing apoptosis and cell cycle arrest in melanoma cells.神经降压素受体 1 拮抗剂 SR48692 通过诱导黑色素瘤细胞凋亡和细胞周期停滞来减少增殖。
Mol Cell Biochem. 2014 Apr;389(1-2):1-8. doi: 10.1007/s11010-013-1920-3. Epub 2013 Dec 20.
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Targeting neurotensin as a potential novel approach for the treatment of autism.以神经降压素为靶点,作为自闭症治疗的一种新的潜在方法。
J Neuroinflammation. 2010 Oct 1;7:58. doi: 10.1186/1742-2094-7-58.
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Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference.
在可卡因戒断期间给予神经降压素受体拮抗剂可降低运动致敏性和条件性位置偏爱。
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Neurochem Res. 2002 Nov;27(11):1555-61. doi: 10.1023/a:1021612825025.
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Constitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix seven.通过螺旋7中Phe(358)的突变导致神经降压素受体1的组成性激活。
Br J Pharmacol. 2002 Feb;135(4):997-1002. doi: 10.1038/sj.bjp.0704546.
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Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating.增强的神经降压素神经传递参与抗精神病药物的临床相关行为效应:来自感觉运动门控动物模型的证据。
J Neurosci. 2001 Jan 15;21(2):601-8. doi: 10.1523/JNEUROSCI.21-02-00601.2001.