Murphy W M
J Urol. 1977 Nov;118(5):811-3. doi: 10.1016/s0022-5347(17)58204-x.
The reluctance to accept urinary cytology as a diagnostic procedure in urologic cancer has been partially owing to a relatively high incidence of falsely positive results. The recent recognition of bladder cancer as a field change and the identification of urothelial dysplasia support the contention that these cytologic findings represent early neoplasia rather than laboratory errors. Of 64 patients with positive or suspicious urinary cytology short-term histologic confirmation could not be obtained in 10. Of these 10 patients review of the clinical and pathologic material was possible in 9 and significant urologic abnormalities were found in 7. Among patients with bladder cancer there were no falsely negative reports. Urinary cytology is a reliable procedure in the diagnosis of urologic malignancies. Unconfirmed positive results require careful examination and followup.
在泌尿系统癌症中，人们不愿将尿液细胞学检查作为一种诊断方法，部分原因是假阳性结果的发生率相对较高。最近将膀胱癌视为一种场效应改变以及对尿路上皮发育异常的识别，支持了这样一种观点，即这些细胞学发现代表早期肿瘤形成而非实验室误差。在64例尿液细胞学检查呈阳性或可疑的患者中，有10例无法在短期内获得组织学确诊。在这10例患者中，有9例能够回顾临床和病理资料，其中7例发现了明显的泌尿系统异常。在膀胱癌患者中，没有假阴性报告。尿液细胞学检查是诊断泌尿系统恶性肿瘤的一种可靠方法。未经证实的阳性结果需要仔细检查和随访。
