Sainte-Laudy J
Unité d'immuno-allergologie clinique, laboratoire Cerba, Cergy-Pontoise, France.
Allerg Immunol (Paris). 1997 Feb;29(2):28-35.
The major role played by leukotrienes in the inflammatory reaction is today clearly demonstrated. These newly-formed mediators show powerful pro-inflammatory activities and their release from various cell types may be induced by agonists including the allergens. Therefore, leukotriene levels in biological fluids may represent a reliable image of the local or systemic inflammatory reaction and their release in vitro after incubation of the blood leukocytes in the presence of a specific allergen is today widely used for allergy diagnosis. Leukotrienes metabolism is deeply involved in aspirin intolerance or so-called pseudo allergy and, in spite of that the exact mechanism involved is still unknown, leukotriene release in vitro by ASA in the presence C5a represent the first reliable test for this diagnosis. The results of the recent clinical trials concerning the activity of anti-leukotrienes in vivo have led to a real therapeutic hope.
如今，白三烯在炎症反应中所起的主要作用已得到明确证实。这些新形成的介质具有强大的促炎活性，包括过敏原在内的激动剂可诱导其从各种细胞类型中释放。因此，生物体液中的白三烯水平可能代表局部或全身炎症反应的可靠指标，如今在特定过敏原存在的情况下，将血液白细胞孵育后体外释放的白三烯已广泛用于过敏诊断。白三烯代谢与阿司匹林不耐受或所谓的假过敏密切相关，尽管其中的确切机制仍不清楚，但在C5a存在的情况下，阿司匹林体外诱导的白三烯释放是该诊断的首个可靠测试。最近关于抗白三烯体内活性的临床试验结果带来了真正的治疗希望。
