• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[毒蕈碱受体在氯氮䓬诱导的大鼠惊厥状态发病机制中的作用]

[The role of the muscarinic receptors in the pathogenesis of the convulsive state induced by korazol in rats].

作者信息

Khobotova Z I, Mukovskiĭ L A, Kosmachev A B, Fil'ko O A, Filippov V N, Dolgo-Saburov V B

出版信息

Eksp Klin Farmakol. 1997 Jan-Feb;60(1):16-8.

PMID:9162273
Abstract

It was established in experiments on albino rats that blockade of the muscarinic receptors by various M-cholinolytics reduces the dose of corazol necessary for the development of a convulsive state. Preliminary administration of some cholinopositive agents raises the corazol action threshold. It is suggested on the basis of pharmacological analysis that the role of the cholinergic system in the pathogenesis of corasol-induced convulsive state in rats is mediated by the function of cholinoreceptors related to subtype M4 or M1.

摘要

在对白化大鼠的实验中确定，各种M-胆碱能阻滞剂对毒蕈碱受体的阻断作用可降低引发惊厥状态所需的戊四氮剂量。预先给予某些胆碱能增强剂可提高戊四氮的作用阈值。基于药理学分析表明，胆碱能系统在大鼠戊四氮诱导的惊厥状态发病机制中的作用是由与M4或M1亚型相关的胆碱能受体功能介导的。

相似文献

1
[The role of the muscarinic receptors in the pathogenesis of the convulsive state induced by korazol in rats].[毒蕈碱受体在氯氮䓬诱导的大鼠惊厥状态发病机制中的作用]
Eksp Klin Farmakol. 1997 Jan-Feb;60(1):16-8.
2
[The properties of the benzodiazepine receptors of the rat cerebellum 6 months after korazol-induced kindling and recurrent seizures].[氯氮䓬诱导点燃和反复癫痫发作6个月后大鼠小脑苯二氮䓬受体的特性]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):304-12.
3
[The properties of the benzodiazepine receptors in the rat cerebellum after acute seizures and the development of korazol-induced kindling].[急性惊厥后大鼠小脑苯二氮䓬受体的特性及氯氮卓诱导点燃的发展]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Jan-Feb;48(1):135-42.
4
Role of muscarinic and nicotinic cholinergic receptors in an experimental model of epilepsy-induced analgesia.毒蕈碱型和烟碱型胆碱能受体在癫痫诱导镇痛实验模型中的作用
Pharmacol Biochem Behav. 2004 Oct;79(2):367-76. doi: 10.1016/j.pbb.2004.08.007.
5
[Effect of M3-choline receptor blockade on the ability of muscarinic antagonists to prevent catalepsy induced by haloperidol in rats].[M3胆碱受体阻断对毒蕈碱拮抗剂预防氟哌啶醇诱导大鼠僵住症能力的影响]
Eksp Klin Farmakol. 2001 Jul-Aug;64(4):10-2.
6
[Changes in the convulsant readiness of mice as affected by korazol].
Farmakol Toksikol. 1984 Mar-Apr;47(2):16-9.
7
Characterization of the muscarinic receptor subtype(s) mediating contraction of the guinea-pig lung strip and inhibition of acetylcholine release in the guinea-pig trachea with the selective muscarinic receptor antagonist tripitramine.用选择性毒蕈碱受体拮抗剂曲匹拉明对介导豚鼠肺条收缩和抑制豚鼠气管乙酰胆碱释放的毒蕈碱受体亚型进行表征。
Br J Pharmacol. 1997 Sep;122(1):133-41. doi: 10.1038/sj.bjp.0701346.
8
[The selectivity and protective properties of m-cholinolytics in dichlorodivinylphosphate poisoning].[间胆碱能阻滞剂在二氯二乙烯基磷酸酯中毒中的选择性及保护特性]
Eksp Klin Farmakol. 1992 May-Jun;55(3):56-8.
9
[The pharmacological differences between kynurenine- and korazol-induced seizures (the participation of GABA-B receptors and dopamine)].犬尿氨酸和氯氮卓诱导的癫痫发作之间的药理学差异（γ-氨基丁酸B受体和多巴胺的参与）
Eksp Klin Farmakol. 1998 Mar-Apr;61(2):20-2.
10
[Comparative pharmacological analysis of M-cholinoreceptors in Daphnia and rats].[水蚤和大鼠中M胆碱能受体的比较药理学分析]
Biull Eksp Biol Med. 1994 May;117(5):497-9.