Danilov A F, Malygin V V
Eksp Klin Farmakol. 1997 Jan-Feb;60(1):25-7.
In experiments on narcotized cats records of contractions of the anterior tibial muscle in response to indirect stimulation showed that the mean dose of acetylcholine (Ach) blocking neuromuscular conduction and that of carbachole (Cch) for their injection into the corresponding femoral artery was 18.9 and 0.16 mumole/kg, respectively. In the period of partial blockade induced by depolarizing myorelaxants, the blocking dose of Ach reduced to a greater measure than that of Cch. Most nondepolarizing myorelaxants used in the experiment increased the blocking Ach dose less than the Cch dose. Benzoquinone possessing the highest antiacetylcholinesterase activity in vitro even reduced the blocking dose of Ach. This difference is apparently due to inhibition of the activity of synaptic acetylcholinesterase by the muscle relaxants.
在对麻醉猫进行的实验中，记录了胫前肌对间接刺激的收缩反应，结果显示，阻断神经肌肉传导的乙酰胆碱（Ach）和卡巴胆碱（Cch）注入相应股动脉的平均剂量分别为18.9和0.16微摩尔/千克。在去极化肌松剂引起的部分阻滞期间，Ach的阻滞剂量比Cch的阻滞剂量降低得更多。实验中使用的大多数非去极化肌松剂增加的Ach阻滞剂量比Cch剂量少。在体外具有最高抗乙酰胆碱酯酶活性的苯醌甚至降低了Ach的阻滞剂量。这种差异显然是由于肌松剂对突触乙酰胆碱酯酶活性的抑制作用。
