Papworth J, Colville-Nash P, Alam C, Seed M, Willoughby D
Department of Experimental Pathology, William Harvey Research Institute, Saint Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, UK.
Eur J Pharmacol. 1997 May 1;325(2-3):R1-R2. doi: 10.1016/s0014-2999(97)83070-1.
Diclofenac in hyaluronan is analgesic and angiostatic. The depletion of substance P may be a common mechanism. Mice received diclofenac, diclofenac in hyaluronan, or saline i.v. for 5 days and snout substance P assessed: saline 2.80 +/- 0.23; 0.5 mg/kg diclofenac 2.03 +/- 0.20 (P < 0.05); diclofenac in hyaluronan 1.88 +/- 0.21 (P < 0.02); capsaicin 1.45 +/- 0.26 fmol/mg tissue (P < 0.005). Substance P recovered by 5 days (diclofenac in hyaluronan, capsaicin) and 24 h (diclofenac). Diclofenac may deplete substance P in analgesia, and hyaluronan prolong the depletion.
透明质酸双氯芬酸具有镇痛和血管抑制作用。P物质的消耗可能是一种共同机制。小鼠静脉注射双氯芬酸、透明质酸双氯芬酸或生理盐水5天，并评估口鼻部P物质：生理盐水组为2.80±0.23；0.5mg/kg双氯芬酸组为2.03±0.20（P<0.05）；透明质酸双氯芬酸组为1.88±0.21（P<0.02）；辣椒素组为1.45±0.26fmol/mg组织（P<0.005）。5天后（透明质酸双氯芬酸、辣椒素）和24小时后（双氯芬酸）P物质恢复。双氯芬酸在镇痛过程中可能消耗P物质，而透明质酸可延长这种消耗。
