Killick S B, Marsh J C, Hale G, Waldmann H, Kelly S J, Gordon-Smith E C
Department of Haematology, St George's Hospital Medical School, London.
Br J Haematol. 1997 May;97(2):306-8. doi: 10.1046/j.1365-2141.1997.612718.x.
We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin and granulocyte-colony stimulating factor, and who was resistant to treatment with azathioprine, cyclosporin and intravenous immunoglobulin. A 10 d course of intravenous Campath-1H monoclonal resulted in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound and prolonged peripheral blood T lymphopenia.
我们报告了一名患有严重自身免疫性中性粒细胞减少症的患者的病程，该患者使用皮质类固醇、抗淋巴细胞球蛋白和粒细胞集落刺激因子仅出现短暂反应，并且对硫唑嘌呤、环孢素和静脉注射免疫球蛋白治疗耐药。静脉注射Campath-1H单克隆抗体10天的疗程导致了持续的血液学反应。Campath-1H的持久效果可能归因于其诱导深刻且持久的外周血T淋巴细胞减少的显著能力。
