Carlisle H J, Stock M J
Department of Psychology, University of California, Santa Barbara 93106, USA.
Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):185-9. doi: 10.1016/s0091-3057(96)00307-3.
This experiment examined whether paradoxical temperature-dependent effects of norepinephrine (NE) can be blocked by the alpha 1-adrenoceptor antagonist WB 4101 (WB) and the Ca(2+)-channel blocker nifedipine. An operant lever-pressing task was used to measure the demand for heat in a cold environment. As noted previously, NE alone (250 micrograms/kg) produced a substantial and significant increase in the demand for heat, and yet post-test colonic temperature (Tc) fell. When tested alone, WB and nifedipine also increased the demand for heat, but this was sufficient to maintain Tc. When combined with NE, WB and nifedipine reduced the demand for heat and the fall in Tc such that there were no differences between the effects of the blockers given alone or with NE. These results indicate that paradoxical thermoregulatory effects of NE in the cold can be antagonized effectively by either an alpha 1-adrenoceptor antagonist or a Ca(2+)-channel blocker.
本实验研究了去甲肾上腺素（NE）的矛盾性温度依赖性效应是否能被α1肾上腺素能受体拮抗剂WB 4101（WB）和钙通道阻滞剂硝苯地平阻断。采用操作性杠杆按压任务来测量寒冷环境中对热量的需求。如先前所述，单独使用NE（250微克/千克）会使对热量的需求显著大幅增加，但测试后结肠温度（Tc）却下降。单独测试时，WB和硝苯地平也会增加对热量的需求，但这足以维持Tc。当与NE联合使用时，WB和硝苯地平降低了对热量的需求以及Tc的下降，使得单独给予阻滞剂或与NE联合使用时的效果没有差异。这些结果表明，寒冷环境中NE的矛盾性体温调节效应可被α1肾上腺素能受体拮抗剂或钙通道阻滞剂有效拮抗。
