Crespo R, Revilla M, Crespo E, Villa L F, Rico H
Department of Medicine, University of Alcalá de Henares, 28801 Madrid, Spain.
Calcif Tissue Int. 1997 Jun;60(6):567-70. doi: 10.1007/s002239900281.
In 45 women with Colles' fracture, two types of complementary medical treatment (calcitonin with calcium [SCT+Ca] and calcium alone [Ca]) were compared with placebo. Consecutive patients were assigned randomly to one of the three study groups at the time of inclusion in the study: 15 women (68.6 +/- 5.7 years) were given 100 IU/day I.M. of SCT plus 1200 mg of elemental Ca for 10 successive days each month; 15 women (71.7 +/- 6.1 years) were given only 1200 mg of elemental Ca for 10 days each month; and 15 women (66.9 +/- 7. 9 years) were treated with placebo. Biochemical and radiogrammetric studies were made at baseline and after 1 year of treatment. In the SCT+Ca group tartrate-resistant acid phosphatase decreased (Wilcoxon test, P = 0.014) and the metacarpal index and the cortical and total area (CA/TA) ratio increased (both P = 0.001). In the group treated with Ca alone, no changes were observed. In the placebo group, the metacarpal index and CA/TA decreased (P = 0.015 and P = 0.007, respectively). Ca alone, at the dosage used here, inhibited bone loss after Colles' fracture. The addition of SCT to Ca administration not only impeded bone loss but significantly increased cortical bone mass.
在45例Colles骨折女性患者中，比较了两种辅助治疗方法（降钙素联合钙剂[SCT+Ca]和单纯钙剂[Ca]）与安慰剂的效果。连续入选的患者在纳入研究时被随机分配到三个研究组之一：15名女性（68.6±5.7岁）每月连续10天接受每日100 IU的肌肉注射SCT加1200 mg元素钙；15名女性（71.7±6.1岁）每月仅接受1200 mg元素钙治疗10天；15名女性（66.9±7.9岁）接受安慰剂治疗。在基线时和治疗1年后进行生化和放射测量研究。在SCT+Ca组中，抗酒石酸酸性磷酸酶降低（Wilcoxon检验，P=0.014），掌骨指数以及皮质骨面积与总面积（CA/TA）之比增加（均为P=0.001）。在单纯钙剂治疗组中，未观察到变化。在安慰剂组中，掌骨指数和CA/TA降低（分别为P=0.015和P=0.007）。此处所用剂量的单纯钙剂可抑制Colles骨折后的骨质流失。在钙剂给药基础上加用SCT不仅可阻止骨质流失，还能显著增加皮质骨量。
