缓释维拉帕米对系统性高血压患者日常活动期间晨间系统性动脉压激增的影响。
Effect of sustained-release Verapamil on the morning systemic arterial pressure surge during daily activity in patients with systemic hypertension.
作者信息
Rosito G A, Gebara O C, McKenna C A, Solomon H S, Muller J E, Tofler G H
机构信息
Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
出版信息
Am J Cardiol. 1997 May 1;79(9):1252-5. doi: 10.1016/s0002-9149(97)00093-3.
In a placebo-controlled study of 13 subjects with systemic hypertension, sustained-release verapamil reduced the morning surge in systolic pressure by 10.2 mm Hg (p = 0.04), diastolic pressure by 11.1 mm Hg (p = 0.008), and heart rate by 3.3 beats/min (p = 0.17). Blunting of the morning hemodynamic surge may be a mechanism by which verapamil could reduce the risk of plaque disruption and acute coronary events in the morning.
在一项针对13名系统性高血压患者的安慰剂对照研究中，缓释维拉帕米使收缩压的晨峰降低了10.2毫米汞柱（p = 0.04），舒张压降低了11.1毫米汞柱（p = 0.008），心率降低了3.3次/分钟（p = 0.17）。减弱早晨的血流动力学波动可能是维拉帕米降低早晨斑块破裂和急性冠脉事件风险的一种机制。
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