Segal B M, Klinman D M, Shevach E M
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
J Immunol. 1997 Jun 1;158(11):5087-90.
The development and exacerbation of autoimmune diseases are associated with antecedent infectious illness. Microbial products such as LPS, bacterial DNA, or oligonucleotides containing an unmethylated cytosine-guanine dinucleotide have cytokine modulating properties. These products converted quiescent myelin basic protein-specific T cells into effector cells capable of transferring experimental allergic encephalomyelitis. The disease-promoting properties of the microbial products were solely dependent on their capacity to induce the production of IL-12.
自身免疫性疾病的发展和加剧与先前的感染性疾病有关。微生物产物如脂多糖、细菌DNA或含有未甲基化胞嘧啶-鸟嘌呤二核苷酸的寡核苷酸具有细胞因子调节特性。这些产物将静止的髓鞘碱性蛋白特异性T细胞转化为能够传递实验性变应性脑脊髓炎的效应细胞。微生物产物的促病特性完全取决于它们诱导白细胞介素-12产生的能力。
