Hermann G G, Andersen C B
Department of Urology, Herlev University Hospital, Copenhagen, Denmark.
Scand J Urol Nephrol. 1997 Apr;31(2):161-6. doi: 10.3109/00365599709070323.
Recently, vitamin D analogues have shown antineoplastic effect in several diseases. Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR). Studies of VDR in transitional cell carcinoma (TCC) have not been reported. The purpose of the present study was therefore to examine whether human bladder tumor cells express VDR. Tumor biopsies were obtained from 26 patients with TCC. Expression of VDR was examined by immunohistochemical experiments. All tumors expressed VDR. Biopsies from advanced disease contained more VDR positive cells than low stage disease (p < 0.05). Similarly, also tumor grade appeared to be related to the number of cells expressing the receptor. Normal urothlium also expressed VDR but only with low intensity. Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D's effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients.
最近，维生素D类似物在几种疾病中显示出抗肿瘤作用。维生素D类似物通过与维生素D受体（VDR）相互作用发挥其作用。尚未见有关VDR在移行细胞癌（TCC）中的研究报道。因此，本研究的目的是检测人膀胱肿瘤细胞是否表达VDR。从26例TCC患者获取肿瘤活检组织。通过免疫组织化学实验检测VDR的表达。所有肿瘤均表达VDR。晚期疾病活检组织中VDR阳性细胞比低分期疾病更多（p<0.05）。同样，肿瘤分级似乎也与表达该受体的细胞数量有关。正常尿道上皮也表达VDR，但强度较低。我们的研究表明，TCC细胞具有VDR受体，这可能使它们能够对维生素D刺激产生反应，但在可以评估维生素D类似物对TCC患者的治疗效果之前，有必要对维生素D对TCC细胞的体外作用进行功能研究。
