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左炔诺孕酮宫内节育系统在月经过多治疗中的应用

The levonorgestrel intrauterine system in the management of menorrhagia.

作者信息

Barrington J W, Bowen-Simpkins P

机构信息

Department of Obstetrics and Gynaecology, Singleton Hospital, Swansea.

出版信息

Br J Obstet Gynaecol. 1997 May;104(5):614-6. doi: 10.1111/j.1471-0528.1997.tb11542.x.

Abstract

OBJECTIVE

To assess the effect of a levonorgestrel releasing intrauterine system in the management of menorrhagia.

DESIGN

A prospective study.

SETTING

A district general hospital in South Wales.

METHODS

Fifty women with a failed trial of medical therapy and awaiting hysterectomy or transcervical resection of the endometrium (TCRE) were treated with a levonorgestrel intrauterine system. The menstrual loss was estimated using a modified pictorial chart together with a full blood count and ferritin measurement preinsertion and at three and six to nine months postinsertion.

RESULTS

The menstrual loss was reduced to acceptable levels in 37 women at three months and a further four by six to nine months. In all, 41 patients were taken off the waiting list for surgery, four of whom became amenorrhoeic. There was no significant change in full blood count nor ferritin measurement despite unscheduled bleeding for six to eight weeks postinsertion. Fifty-six percent of patients noticed considerable improvement or cure of their premenstrual syndrome symptoms; 80% noted a reduction in dysmenorrhoea.

CONCLUSION

The levonorgestrel releasing intrauterine system is an effective nonsurgical treatment for the management of menorrhagia and dysmenorrhoea that has additional benefit as a contraceptive and in relieving premenstrual syndrome.

摘要

目的

评估左炔诺孕酮宫内节育系统治疗月经过多的效果。

设计

一项前瞻性研究。

地点

南威尔士的一家区综合医院。

方法

五十名药物治疗失败且等待子宫切除术或子宫内膜经宫颈切除术(TCRE)的女性接受了左炔诺孕酮宫内节育系统治疗。使用改良的图像图表,并在放置前以及放置后三个月和六至九个月进行全血细胞计数和铁蛋白测量,以估计月经量。

结果

三个月时,37名女性的月经量减少到可接受水平,六至九个月时又有4名女性的月经量减少。共有41名患者从手术等候名单中移除,其中4名出现闭经。尽管放置后六至八周出现不规则出血,但全血细胞计数和铁蛋白测量均无显著变化。56%的患者注意到经前综合征症状有显著改善或治愈;80%的患者注意到痛经减轻。

结论

左炔诺孕酮宫内节育系统是治疗月经过多和痛经的一种有效的非手术方法,作为一种避孕措施以及缓解经前综合征还有额外益处。

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