Rust O A, Bofill J A, Zappe D H, Hall J E, Burnett J C, Martin J N
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.
Obstet Gynecol. 1997 May;89(5 Pt 1):754-7. doi: 10.1016/s0029-7844(97)00093-8.
To determine the site of origin of increased concentrations of plasma endothelin-1 in patients with severe preeclampsia.
Twelve patients with severe preeclampsia undergoing an indicated abdominal delivery had endothelin-1 levels measured from plasma specimens drawn from right and left uterine and antecubital veins before delivery and after placenta removal with uterine curettage. Twelve uncomplicated control patients undergoing abdominal delivery had endothelin-1 concentrations drawn by an identical protocol. Clinical staff members were blinded to endothelin-1 results and laboratory staff were blinded to patient group assignment and sample source. Endothelin-1 plasma concentrations were determined by radioimmunoassay and data were analyzed by paired t test.
No difference in endothelin-1 concentration was noted with respect to placental location, central versus peripheral, or predelivery versus postdelivery sampling procedures. Overall, patients with preeclampsia had higher plasma concentrations of endothelin-1 (mean 11.0 +/- 6.6 pg/mL) compared with normotensive patients (mean 8.4 +/- 6.7 pg/mL, P < .005).
The decidual-placental interface does not appear to be the source of increased plasma endothelin-1 concentrations found in severe preeclampsia. The origin of this increase remains uncertain.
确定重度子痫前期患者血浆内皮素-1浓度升高的来源部位。
12例接受择期剖宫产的重度子痫前期患者，在分娩前及刮宫清除胎盘后，分别从左右子宫静脉和肘前静脉采集血浆标本，测定内皮素-1水平。12例接受剖宫产的无并发症对照患者按相同方案采集内皮素-1浓度。临床工作人员对内皮素-1结果不知情，实验室工作人员对患者分组和样本来源不知情。采用放射免疫法测定血浆内皮素-1浓度，数据采用配对t检验进行分析。
在内皮素-1浓度方面，胎盘位置（中央与外周）、分娩前与分娩后采样程序之间均未发现差异。总体而言，子痫前期患者的血浆内皮素-1浓度（平均11.0±6.6 pg/mL）高于血压正常的患者（平均8.4±6.7 pg/mL，P<.005）。
蜕膜-胎盘界面似乎不是重度子痫前期患者血浆内皮素-1浓度升高的来源。这种升高的来源仍不确定。
