Martin D, Winter S S, Gardner M O, Nicklaus P
Department of Obstetrics and Gynecology, School of Medicine, University of New Mexico Health Science Center, Albuquerque, USA.
Obstet Gynecol. 1997 May;89(5 Pt 2):828-31. doi: 10.1016/s0029-7844(97)00034-3.
Rhabdomyosarcoma is an aggressive tumor that is rarely found in pregnancy, and is usually treated with multiagent chemotherapy. Chemotherapy given during pregnancy is associated with several maternal-fetal complications, including risks for mutagenicity, myelosuppression, and fetal death.
An 18-year-old woman had stage III facial rhabdomyosarcoma diagnosed early in the third trimester. She achieved clinical remission with multiagent chemotherapy given during pregnancy, with no fetal complications.
Invasive rhabdomyosarcoma is biologically predisposed to metastasize, and in the absence of effective chemotherapy, most patients will develop sites of distant recurrence. Chemotherapy plays an important role as frontline treatment in pregnant women with rhabdomyosarcoma.
横纹肌肉瘤是一种侵袭性肿瘤，在孕期很少见，通常采用多药化疗进行治疗。孕期进行化疗会引发多种母婴并发症，包括致突变性、骨髓抑制和胎儿死亡风险。
一名18岁女性在孕晚期早期被诊断为III期面部横纹肌肉瘤。她在孕期接受多药化疗后实现临床缓解，且未出现胎儿并发症。
侵袭性横纹肌肉瘤具有生物学上的转移倾向，在缺乏有效化疗的情况下，大多数患者会出现远处复发部位。化疗在患有横纹肌肉瘤的孕妇的一线治疗中起着重要作用。
