Smith M B, Schnadig V J, Zaharopoulos P, Van Hook C
Department of Pathology, University of Texas Medical Branch, Galveston, USA.
Obstet Gynecol. 1997 May;89(5 Pt 2):842-4. doi: 10.1016/s0029-7844(97)81426-3.
Histoplasma capsulatum infection in adults is most often subclinical but can result in disseminated disease with weight loss, fever, hepatosplenomegaly, and oropharyngeal ulcerations. Genital ulceration as the presenting sign of the disease has been reported rarely.
A 63-year-old woman presented with multiple vaginal ulcerations due to chronic disseminated H capsulatum infection. Initial diagnosis was made by Papanicolaou and Giemsa-stained vulvar smears. Ketoconazole therapy resulted in clearing of the lesions in 5 weeks.
Chronic disseminated histoplasmosis is an insidious and potentially fatal disease that can present rarely as genital mucocutaneous ulcerations in women. Prompt presumptive diagnosis can be accomplished by examination of smears obtained by ulcer abrasion, permitting institution of appropriate therapy.
成人荚膜组织胞浆菌感染大多为亚临床感染，但可导致播散性疾病，出现体重减轻、发热、肝脾肿大及口咽溃疡。该病以生殖器溃疡为首发症状的报道极为罕见。
一名63岁女性因慢性播散性荚膜组织胞浆菌感染出现多处阴道溃疡。最初通过巴氏染色和吉姆萨染色的外阴涂片进行诊断。酮康唑治疗5周后病变消退。
慢性播散性组织胞浆菌病是一种隐匿且可能致命的疾病，在女性中极少表现为生殖器黏膜皮肤溃疡。通过检查溃疡刮取物涂片可迅速做出初步诊断，从而能够及时进行恰当治疗。
