Maacke H, Kessler A, Schmiegel W, Roeder C, Vogel I, Deppert W, Kalthoff H
Heinrich-Pette-Institut für Experimentelle Immunologie und Virologie, Universität Hamburg, Germany.
Br J Cancer. 1997;75(10):1501-4. doi: 10.1038/bjc.1997.256.
Overexpression of p53 correlates with neoplasia in many cytological specimens. To test the specificity of overexpressed p53 as a tumour marker for the detection of pancreatic cancer, we analysed cytological specimens of pancreatic juice samples from patients with pancreatitis or pancreatic carcinoma (n = 42) for p53 protein overexpression. p53 protein overexpression was found in 59% of patients with pancreatitis and 67% of patients with pancreatic carcinoma. Thus, the assessment of p53 protein overexpression is not useful in the diagnosis of pancreatic cancer. Overexpressed p53 during pancreatitis appears to be wild-type p53. Overexpression of p53 may result from DNA damage occurring during chronic inflammation. It is well established that p53 can induce apoptosis upon DNA damage. Consequently, we found apoptotic cell death in five out of five tested cytological preparations from patients with pancreatitis as well as in one out of one pancreatic carcinoma specimen.
在许多细胞学标本中，p53的过表达与肿瘤形成相关。为了测试过表达的p53作为检测胰腺癌的肿瘤标志物的特异性，我们分析了胰腺炎或胰腺癌患者（n = 42）的胰液样本的细胞学标本中p53蛋白的过表达情况。在59%的胰腺炎患者和67%的胰腺癌患者中发现了p53蛋白过表达。因此，评估p53蛋白过表达对胰腺癌的诊断并无帮助。胰腺炎期间过表达的p53似乎是野生型p53。p53的过表达可能源于慢性炎症期间发生的DNA损伤。众所周知，p53可在DNA损伤时诱导细胞凋亡。因此，我们在来自胰腺炎患者的五个测试细胞学制剂中的五个以及在一个胰腺癌标本中发现了凋亡细胞死亡。
