Clyne M, Drumm B
Department of Paediatrics, University College Dublin, Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Ireland.
Can J Gastroenterol. 1997 Apr;11(3):243-8. doi: 10.1155/1997/149734.
Bacterial adhesion to the intestinal epithelium is a critical initial step in the pathogenesis of many enteric diseases. Helicobacter pylori is a duodenal pathogen that adheres to the gastric epithelium and causes gastritis and peptic ulceration. The mechanism by which H pylori causes disease has not been elucidated but adherence to the gastric mucosa is thought to be an important virulence determinant of the organism. What is known about adherence of H pylori to the gastric mucosa is summarized. Topics discussed are the mechanism of H pylori adherence; in vitro and in vivo models of H pylori infection; and adherence and potential adhesins and receptors for H pylori.
细菌黏附于肠道上皮是许多肠道疾病发病机制中的关键起始步骤。幽门螺杆菌是一种十二指肠病原体，它黏附于胃上皮并导致胃炎和消化性溃疡。幽门螺杆菌致病的机制尚未阐明，但黏附于胃黏膜被认为是该生物体重要的毒力决定因素。本文总结了关于幽门螺杆菌黏附于胃黏膜的已知情况。讨论的主题包括幽门螺杆菌的黏附机制；幽门螺杆菌感染的体外和体内模型；以及幽门螺杆菌的黏附、潜在黏附素和受体。
