白细胞介素-2受体α链表达在急性白血病中的临床意义。日本白血病/淋巴瘤协作组。
Clinical importance of interleukin-2 receptor alpha-chain expression in acute leukemia. The Japan Cooperative Group of Leukemia/Lymphoma.
作者信息
Nakase K, Kita K, Kageyama S, Tsuji K, Miyanishi E, Miwa H, Tanaka I, Shirakawa S, Tanaka I, Anazawa H, Tsutani H, Kyo T, Dohy H, Kamada N, Doi S, Nasu K, Uchino H
机构信息
Department of Internal Medicine, Yamada Red Cross Hospital, Misono, Japan.
出版信息
Cancer Detect Prev. 1997;21(3):273-9.
To clarify the clinical importance of interleukin-2 (IL-2) receptor (IL-2R) expression in acute leukemia, we examined 517 adult patients with acute leukemia and CML blast crisis (CML-BC). IL-2R alpha was expressed in 42/311 AML, 5/11 acute unclassified leukemia, 24/116 pre-B ALL, 2/32 T-ALL, and 27/47 CML-BC, while IL-2R beta was expressed only in 2 T-ALL. Expression of IL-2R alpha was closely associated with that of different lineage markers, CD11b, CD34, and Ph1+ abnormality. IL-2R alpha(+) non-T leukemic cells did not respond to IL-2. Clinical outcome of IL-2R alpha (+) leukemia showed lower response to conventional chemotherapy and poorer prognosis than IL-2R alpha (-) cases. Serum IL-2R alpha level in IL-2R alpha (+) cases increased at the onset. Our findings indicate the diagnostic importance of IL-2R alpha expression in acute leukemia as a prognostic risk factor with a close relation to the particular cellular characteristics.
为阐明白细胞介素-2（IL-2）受体（IL-2R）表达在急性白血病中的临床重要性，我们研究了517例成年急性白血病和慢性粒细胞白血病急变期（CML-BC）患者。IL-2Rα在42/311例急性髓系白血病（AML）、5/11例急性未分类白血病、24/116例前B淋巴细胞白血病（ALL）、2/32例T淋巴细胞白血病（T-ALL）以及27/47例CML-BC中表达，而IL-2Rβ仅在2例T-ALL中表达。IL-2Rα的表达与不同谱系标志物CD11b、CD34以及Ph1+异常密切相关。IL-2Rα(+)非T白血病细胞对IL-2无反应。与IL-2Rα(-)病例相比，IL-2Rα(+)白血病的临床结局显示对传统化疗的反应较低且预后较差。IL-2Rα(+)病例血清IL-2Rα水平在发病时升高。我们的研究结果表明，IL-2Rα表达在急性白血病中作为一种预后危险因素具有诊断重要性，且与特定细胞特征密切相关。
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