Vanberkum M F
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA.
Perspect Dev Neurobiol. 1996;4(2-3):227-36.
The searching growth cone simultaneously processes multiple guidance cues and converts them into intracellular signals regulating axon extension, steering and eventually synapse formation. This overlap of signaling pathways ensures functional connectivity of the nervous system during development. While this complicates the genetic analysis of these signaling pathways, combination of genetic techniques available in Drosophila has begun to successfully address the role of some key signaling molecules during axon guidance.
正在搜寻的生长锥同时处理多种导向线索，并将它们转化为调节轴突延伸、转向以及最终突触形成的细胞内信号。这些信号通路的重叠确保了发育过程中神经系统的功能连接性。虽然这使得对这些信号通路的遗传分析变得复杂，但果蝇中可用的遗传技术组合已开始成功地阐明一些关键信号分子在轴突导向过程中的作用。
