用微探针X射线吸收光谱法测定V79中国仓鼠肺细胞暴露于遗传毒性铬络合物后细胞内铬的氧化态。
Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes.
作者信息
Dillon C T, Lay P A, Cholewa M, Legge G J, Bonin A M, Collins T J, Kostka K L, Shea-McCarthy G
机构信息
School of Chemistry, University of Sydney, NSW, Australia.
出版信息
Chem Res Toxicol. 1997 May;10(5):533-5. doi: 10.1021/tx970010m.
The oxidation state of intracellular chromium has been determined directly in mammalian lung cells exposed to mutagenic and carcinogenic chromium compounds. Microprobe X-ray absorption spectroscopy (XAS) experiments on single V79 Chinese hamster lung cells showed that Cr(VI) and Cr(V) complexes were reduced completely (>90%) to Cr(III) within 4 h of exposure of the cells. This result provides direct evidence for the hypothesis that these genotoxic oxidants react rapidly with intracellular reductants.
在暴露于致突变和致癌铬化合物的哺乳动物肺细胞中，已直接测定了细胞内铬的氧化态。对单个V79中国仓鼠肺细胞进行的微探针X射线吸收光谱（XAS）实验表明，在细胞暴露后4小时内，Cr(VI)和Cr(V)络合物完全（>90%）还原为Cr(III)。这一结果为这些基因毒性氧化剂与细胞内还原剂快速反应的假说提供了直接证据。
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