Nasr F, Macintyre E, Venuat A M, Bayle C, Carde P, Ribrag V
Service de Médecine C., Institut Gustave-Roussy, Villejuif, France.
Leuk Lymphoma. 1997 Apr;25(3-4):399-401. doi: 10.3109/10428199709114180.
Secondary therapy-related, acute lymphoblastic leukemia (S-ALL) is less common than its myeloblastic counterpart. S-ALL with MLL gene rearrangements have only been reported on six previous occasions. Only three of these had t(4;11)(q21;23) S-ALL with MLL-AF4 fusion transcript has only been reported in one earlier case. In this report a rare case of S-ALL with MLL-AF4 transcript is described in a 36 year old woman treated for breast carcinoma with chemotherapy which included the topoisomerase II inhibitor, VP-16. The precise incidence of MLL gene rearrangement in S-ALL still remains to be clarified.
