• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin.

作者信息

Ogura T, Tatemichi M, Esumi H

机构信息

Investigative Treatment Division, National Cancer Center Research Institute, Chiba, Japan.

出版信息

Biochem Biophys Res Commun. 1997 Apr 28;233(3):788-91. doi: 10.1006/bbrc.1997.6558.

DOI:10.1006/bbrc.1997.6558
PMID:9168934
Abstract

The human neuroblastoma cell line NB-39-nu expressed inducible nitric oxide synthase (iNOS) mRNA following treatment with a combination of interferon-gamma (IFN-gamma) and cis-diamminedichloroplatinum(II) (cisplatin). The level of iNOS mRNA peaked at 48 hr after treatment, and dexamethasone inhibited the induction of iNOS mRNA expression. Cisplatin induced tumor necrosis factor-alpha (TNF-alpha) mRNA expression, and an anti-TNF-alpha neutralizing antibody inhibited the induction of iNOS expression by a combination of cisplatin and IFN-gamma in NB-39-nu cells. Thus, iNOS expression in NB-39-nu cells by a combination of cisplatin and IFN-gamma involves in the TNF-alpha-mediated signal transduction mechanism.

摘要

相似文献

1
TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin.
Biochem Biophys Res Commun. 1997 Apr 28;233(3):788-91. doi: 10.1006/bbrc.1997.6558.
2
Bryostatin-1 and IFN-gamma synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages.苔藓抑素-1与γ干扰素协同作用，促进小鼠巨噬细胞中诱导型一氧化氮合酶基因的表达及一氧化氮的产生。
Cancer Res. 1997 Jun 15;57(12):2468-73.
3
Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.在与经干扰素-γ刺激的RAW 264.7细胞共培养的肿瘤启动子敏感型而非肿瘤启动子抗性的JB6小鼠表皮细胞中，一氧化氮合酶被诱导：肿瘤坏死因子-α的作用。
Cancer Res. 2000 Nov 15;60(22):6326-31.
4
Regulation of lipopolysaccharide-induced NO synthase expression in the major organs in a mouse model. The roles of endogenous interferon-gamma, tumor necrosis factor-alpha and interleukin-10.小鼠模型中主要器官内脂多糖诱导的一氧化氮合酶表达的调控。内源性干扰素-γ、肿瘤坏死因子-α和白细胞介素-10的作用。
Eur Cytokine Netw. 2000 Mar;11(1):39-46.
5
Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages.肿瘤坏死因子α和核因子κB在γ干扰素诱导巨噬细胞产生诱导型一氧化氮合酶中的作用
J Leukoc Biol. 2007 Jan;81(1):272-83. doi: 10.1189/jlb.0905529. Epub 2006 Oct 11.
6
Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells.诱导型一氧化氮合酶的诱导是肿瘤坏死因子-α诱导MCF-7及其他上皮肿瘤细胞凋亡的重要组成部分。
Lab Invest. 1999 Dec;79(12):1703-12.
7
Nitric oxide and tumor necrosis factor-alpha production by oleanolic acid via nuclear factor-kappaB activation in macrophages.齐墩果酸通过激活巨噬细胞中的核因子-κB产生一氧化氮和肿瘤坏死因子-α
Biochem Biophys Res Commun. 2001 Oct 19;288(1):49-55. doi: 10.1006/bbrc.2001.5727.
8
Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation.肿瘤坏死因子α和干扰素γ在诱导小胶质细胞产生一氧化氮中的互补作用。
J Neuroimmunol. 2008 Nov 15;204(1-2):101-9. doi: 10.1016/j.jneuroim.2008.07.002.
9
Inducible nitric oxide synthase expression and erythropoietin production in human hepatocellular carcinoma cells.人肝癌细胞中诱导型一氧化氮合酶的表达及促红细胞生成素的产生
Biochem Biophys Res Commun. 1997 Mar 27;232(3):702-6. doi: 10.1006/bbrc.1997.6323.
10
Effect of mast cell granules on the gene expression of nitric oxide synthase and tumour necrosis factor-alpha in macrophages.肥大细胞颗粒对巨噬细胞中一氧化氮合酶和肿瘤坏死因子-α基因表达的影响。
Mediators Inflamm. 1998;7(5):355-61. doi: 10.1080/09629359890884.

引用本文的文献

1
Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity.氧化应激和炎症通过胶质细胞激活和缝隙连接蛋白表达失调导致实验性苯乙烯诱导的耳毒性/神经毒性的听觉系统损伤。
J Neuroinflammation. 2024 Jan 4;21(1):4. doi: 10.1186/s12974-023-02996-3.
2
Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events.小胶质细胞衍生的肿瘤坏死因子-α 驱动阿尔茨海默病相关的神经元细胞周期事件。
Neurobiol Dis. 2014 Feb;62:273-85. doi: 10.1016/j.nbd.2013.10.007. Epub 2013 Oct 17.
3
The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.
作为阿尔茨海默病氧化应激源的小胶质细胞NADPH氧化酶复合物
J Neuroinflammation. 2006 Nov 9;3:30. doi: 10.1186/1742-2094-3-30.
4
beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.β-淀粉样蛋白对小胶质细胞和单核细胞的刺激导致诱导型一氧化氮合酶的肿瘤坏死因子α依赖性表达及神经元凋亡。
J Neurosci. 2001 Feb 15;21(4):1179-88. doi: 10.1523/JNEUROSCI.21-04-01179.2001.