用丝状线虫巴西日圆线虫感染BALB/c小鼠：CD4 + T细胞在控制幼虫发育中的作用
Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development.
作者信息
Al-Qaoud K M, Taubert A, Zahner H, Fleischer B, Hoerauf A
机构信息
Department of Medical Microbiology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
出版信息
Infect Immun. 1997 Jun;65(6):2457-61. doi: 10.1128/iai.65.6.2457-2461.1997.
Abstract
Litomosoides sigmodontis is the only filaria which develops from infective larvae into adults in immunocompetent laboratory mice. Depletion of CD4+ T cells from infected BALB/c mice resulted in worm and microfilarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongly induced in infected controls, were diminished in CD4-depleted mice.
摘要
巴西日圆线虫是唯一一种能在免疫功能正常的实验室小鼠体内从感染性幼虫发育为成虫的丝虫。从感染的BALB/c小鼠体内清除CD4+ T细胞，导致蠕虫和微丝蚴负荷显著高于感染对照组。在感染对照组中被强烈诱导的Th2细胞因子、嗜酸性粒细胞增多和免疫球蛋白E，在CD4细胞耗竭的小鼠中减少。
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