Horton A R, Davies A M, Buj-Bello A, Bartlett P, Murphy M
School of Biological and Medical Sciences, University of St. Andrews, Fife, Scotland.
Perspect Dev Neurobiol. 1996;4(1):35-8.
Leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), and related proteins are potentially involved in several aspects of sensory neuron development. There is evidence that LIF promotes the differentiation of sensory neurons from progenitor cells of neural crest origin. Later in development, LIF, CNTF, oncostatin M and interleukin-6 promote the survival of cultured neurons. Some neurons, like those of the nodose ganglion, respond early in their development to these factors, whereas other neurons, like those of the trigeminal ganglion, respond much later. In addition to promoting sensory neuron survival, there is some evidence that LIF is able to influence neurotransmitter and neuropeptide expression in these neurons. These observations suggest that several kinds of sensory neurons may be influenced in various ways by LIF and related factors at different stages of their development.
白血病抑制因子（LIF）、睫状神经营养因子（CNTF）及相关蛋白可能参与感觉神经元发育的多个方面。有证据表明，LIF可促进神经嵴来源的祖细胞分化为感觉神经元。在发育后期，LIF、CNTF、抑瘤素M和白细胞介素-6可促进培养神经元的存活。一些神经元，如结状神经节的神经元，在其发育早期对这些因子有反应，而其他神经元，如三叉神经节的神经元，则在很久之后才有反应。除了促进感觉神经元存活外，有证据表明LIF能够影响这些神经元中神经递质和神经肽的表达。这些观察结果表明，几种感觉神经元在其发育的不同阶段可能受到LIF及相关因子的多种影响。
