Sciagrà R, Bisi G, Buonamici P, Zerauschek F, Santoro G M, Meldolesi U, Fazzini P F, Pupi A
Department of Clinical Pathophysiology, University of Florence, Italy.
J Nucl Med. 1997 May;38(5):766-70.
The aim of this study was to assess the value of the cavity-to-myocardium count ratio (C/M ratio) calculated in resting 99mTc-sestamibi SPECT images to identify patients with depressed left ventricular ejection fraction (LVEF).
In the 95 patients studied, the C/M ratio was calculated from the midventricular short-axis slice using regions of interest drawn in the center of the cavity and in the most active area of the ventricular wall; its value was compared with LVEF measured using two-dimensional echocardiography.
The C/M ratio correlated with LVEF (r = 0.6, p < 0.000001) and was significantly lower in patients with abnormal LVEF than those with normal LVEF: 0.026 +/- 0.028 versus 0.125 +/- 0.093, p < 0.000001. In the entire patient population, a C/M ratio < 0.07 identified the patients with depressed LVEF with a 94% sensitivity, 71% specificity and 82% accuracy.
The resting 99mTc-sestamibi C/M ratio is a useful parameter in identifying patients with depressed LVEF directly from the SPECT perfusion images.
本研究的目的是评估在静息状态下99mTc-甲氧基异丁基异腈单光子发射计算机断层扫描（SPECT）图像中计算的腔室与心肌计数比（C/M比）对识别左心室射血分数（LVEF）降低患者的价值。
在研究的95例患者中，使用在腔室中心和心室壁最活跃区域绘制的感兴趣区，从心室短轴中段切片计算C/M比；将其值与使用二维超声心动图测量的LVEF进行比较。
C/M比与LVEF相关（r = 0.6，p < 0.000001），LVEF异常的患者的C/M比显著低于LVEF正常的患者：0.026±0.028与0.125±0.093，p < 0.000001。在整个患者群体中，C/M比<0.07识别LVEF降低患者的灵敏度为94%，特异度为71%，准确度为82%。
静息状态下的99mTc-甲氧基异丁基异腈C/M比是直接从SPECT灌注图像中识别LVEF降低患者的有用参数。
