Buchner A, David R, Carpenter W, Leider A
Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
Oral Dis. 1996 Dec;2(4):299-302. doi: 10.1111/j.1601-0825.1996.tb00242.x.
To report a case of lateral periodontal cyst (LPC) with marked melanin pigmentation in a 38-year-old Black male and to discuss the phenomenon of melanin pigmentation in odontogenic cysts and tumors.
Histologically, the epithelial lining of the LPC contained an abundant amount of melanin granules throughout the entire epithelium. Ultrastructurally, epithelial cells contained mature melanosomes (stage IV melanosomes). Melanophages containing aggregates of melanosomes were identified in the connective tissue cyst wall. Perusal of the literature revealed that melanin pigmentation in odontogenic lesions is uncommon. Melanin has been reported in calcifying odontogenic cyst (18 cases), odontogenic keratocyst (8 cases), adenomatoid odontogenic tumor (3 cases), ameloblastic fibroma (3 cases), odontoma (2 cases), and ameloblastic fibro-odontoma, odonto-ameloblastoma, and odontogenic fibroma (1 case each).
Almost all pigmented odontogenic lesions; occurred in Blacks and Asians; they are almost non-existent in Whites. Thus, racial pigmentation probably plays an important role in such lesions.
报告1例38岁黑人男性患有的伴有显著黑色素沉着的侧方牙周囊肿（LPC）病例，并探讨牙源性囊肿和肿瘤中的黑色素沉着现象。
组织学上，LPC的上皮衬里在整个上皮中含有大量黑色素颗粒。超微结构上，上皮细胞含有成熟的黑素小体（IV期黑素小体）。在结缔组织囊肿壁中鉴定出含有黑素小体聚集物的噬黑素细胞。查阅文献发现，牙源性病变中的黑色素沉着并不常见。据报道，在钙化牙源性囊肿（18例）、牙源性角化囊肿（8例）、腺样牙源性肿瘤（3例）、成釉细胞纤维瘤（3例）、牙瘤（2例）以及成釉细胞纤维牙瘤、牙釉质成釉细胞瘤和牙源性纤维瘤（各1例）中存在黑色素。
几乎所有色素沉着的牙源性病变均发生在黑人和亚洲人身上；在白人中几乎不存在。因此，种族色素沉着可能在这类病变中起重要作用。
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