Rodrigues-Fernandes Carla-Isabelly, Bonan Paulo-Rogério-Ferreti, Carvalho Elaine-Judite-de Amorim, Sánchez-Romero Celeste, de Almeida Oslei-Paes, Perez Danyel-Elias-da Cruz
DDS, MSc student, Piracicaba Dental School, Oral Pathology Area, State University of Campinas, Piracicaba, São Paulo, Brazil.
DDS, PhD, School of Dentistry, Stomatology Unit, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.
J Clin Exp Dent. 2018 Dec 1;10(12):e1230-e1234. doi: 10.4317/jced.55134. eCollection 2018 Dec.
Pigmented odontogenic keratocyst (OKC) is very rare and its etiology remains uncertain. To the best of our knowledge, only 9 cases of pigmented OKC have been published in English-language literature. This report describes a pigmented OKC in a 14-year-old black male patient. Radiographically, the lesion appeared as a well-circumscribed, unilocular, and radiolucent image. A surgical excision was performed. Histopathological examination revealed an OKC. Additionally, a brownish, sparsed, intracytoplasmic pigmentation was observed in the basal cell layer, which was positive for Fontana-Masson staining. Immunohistochemistry reactions revealed positive dendritic cells for S-100 protein, HMB45 and Melan A. No clinical and imaging signs of recurrence were observed after 24 months. In conclusion, melanin apparently does not represent a factor for distinct biological behavior in OKC. Melanin, melanocytes, odontogenic cyst, odontogenic keratocyst, pigmented.
色素沉着性牙源性角化囊肿（OKC）非常罕见，其病因仍不确定。据我们所知，英文文献中仅发表了9例色素沉着性OKC。本报告描述了一名14岁黑人男性患者的色素沉着性OKC。影像学上，病变表现为边界清晰、单房性的透射影像。进行了手术切除。组织病理学检查显示为OKC。此外，在基底细胞层观察到褐色、稀疏的胞质内色素沉着，Fontana-Masson染色呈阳性。免疫组化反应显示S-100蛋白、HMB45和Melan A的树突状细胞呈阳性。24个月后未观察到复发的临床和影像学征象。总之，黑色素显然不是OKC中独特生物学行为的一个因素。黑色素、黑素细胞、牙源性囊肿、牙源性角化囊肿、色素沉着。
