Curran M, Middleton D, Edwardson J, Perry R, McKeith I, Morris C, Neill D
Tissue Typing Laboratory, Belfast City Hospital, UK.
Neuroreport. 1997 Apr 14;8(6):1467-9. doi: 10.1097/00001756-199704140-00028.
Hla-dr antigen types were determined from DNA isolated from post-mortem brain tissue of age-matched groups of 78 patients with pathologically confirmed late-onset Alzheimer's disease (AD) and 50 controls. The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD. Conversely the DR4 or 6 antigens are associated with a decreased risk of similar magnitude. This DR effect, rather than prolonged use of non-steroidal anti-inflammatory drugs, could be responsible for the reported lower prevalence of AD in rheumatoid arthritis (a condition associated with an increased frequency of DR-4).
从78例经病理确诊为晚发性阿尔茨海默病（AD）的患者以及50名对照者的年龄匹配组的尸检脑组织中分离出的DNA，测定了Hla-dr抗原类型。结果表明，对于没有载脂蛋白E ε4等位基因的个体，DR1、2或3抗原的存在与晚发性AD发病风险显著增加相关。相反，DR4或6抗原与同等程度的风险降低相关。这种DR效应，而非长期使用非甾体抗炎药，可能是类风湿性关节炎（一种与DR-4频率增加相关的疾病）中AD患病率较低的原因。
