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[口腔颌面外科癌症所致面部疼痛的管理]

[Management of facial pain resulting from cancer in oral and maxillofacial surgery].

作者信息

Chiarini L, Stacca R, Bertoldi C, Malagnino F, Pollastri G, Narni F

机构信息

Dipartimento di Chirurgia, Università degli Studi, Modena.

出版信息

Minerva Stomatol. 1997 Jan-Feb;46(1-2):27-38.

PMID:9173214
Abstract

Pain, which is among the most prevalent symptoms experienced by cancer patients, must absolutely be treated. The most important biologic effects of this sort of pain plays on patients' psychosociality. This is in reference to the quality of pain, the amount of pain and to the character of the patients. Actually, pain only in appearance is presented as a symptom; it is usually a disease. Patient assessment, the use of anticancer therapies and systematically administered non-opioid and opioid analgesics are pivotal. Practical aspects of cancer pain treatment include both drug selection, method of analgesic administration: selection of the appropriate route, dose titration and an understanding of the management of side effects. Pain therapy includes another series of possibilities like the use of adjuvant analgesics, psychological therapies, physiatric techniques and invasive interventions such as the use of intraspinal drugs, neural blockade and neuroablative techniques. This kind of therapy must be employed at all times, whether the case may be resolved surgically or not. So we think that pain can be effectively treated. This study was carried out to obtain the correct therapeutic approach for facial cancer pain syndrome. The research was performed on seven women and thirteen men with a mean age of 58 years. All the patients' clinical appearances were standardized with care. Study participants included odontostomatologists and anesthesiologists with experience of controlling cancer pain. The sensation of pain was quantified by means of the Visual Analogue Scale (VAS) while their psychosocial ability was assessed with the Karnofsky Performance Scale (KPS). In this way the authors hoped to obtain a good quality of standardization. The study was performed for a period of two months. The conclusions are that Trans Epidermis Nervous Stimulation (TENS) offers positive results for variable periods and only in 60% of patients with a low level of pain. The use of antiphlogistic non-steroid drugs and of opioid drugs, with a particular management requested from the personal clinical status of each patient, result as being the most effective therapeutic resource. Such therapies must be employed, whether the case may be resolved surgically or not. Nevertheless it is necessary to realize that drugs or other therapies for cancer pain are independent and propaedeutic to each surgical approach. Finally, the use of opioids is addressed in the management of patients with pain that is refractory to other interventions. This approach can provide adequate relief to the vast majority of patients. We find the morphinomania risk in cancer pain patients is not scientifically wellfounded.

摘要

疼痛是癌症患者最普遍经历的症状之一,必须得到绝对的治疗。这种疼痛对患者心理社会状况产生的最重要的生物学影响,涉及疼痛的性质、疼痛程度以及患者的性格特点。实际上,疼痛表面上只是一种症状,通常却是一种疾病。患者评估、抗癌疗法的使用以及系统给予的非阿片类和阿片类镇痛药至关重要。癌症疼痛治疗的实际方面包括药物选择、镇痛给药方法:选择合适的途径、剂量滴定以及对副作用管理的理解。疼痛治疗还包括一系列其他可能性,如使用辅助镇痛药、心理疗法、物理治疗技术以及侵入性干预措施,如使用脊髓内药物、神经阻滞和神经毁损技术。无论病例是否可通过手术解决,这种治疗都必须始终采用。所以我们认为疼痛可以得到有效治疗。本研究旨在获得面部癌痛综合征的正确治疗方法。该研究对7名女性和13名男性进行,平均年龄为58岁。所有患者的临床表现都经过仔细标准化。研究参与者包括有控制癌痛经验的口腔颌面外科医生和麻醉师。疼痛感觉通过视觉模拟量表(VAS)进行量化,而他们的心理社会能力则用卡诺夫斯基功能状态量表(KPS)进行评估。通过这种方式,作者希望获得高质量的标准化。该研究进行了两个月。结论是经皮神经电刺激(TENS)在不同时间段内对60%疼痛程度较低的患者产生了积极效果。使用消炎非甾体药物和阿片类药物,并根据每个患者的个人临床状况进行特殊管理,是最有效的治疗资源。无论病例是否可通过手术解决,都必须采用这种治疗方法。然而,有必要认识到,用于癌症疼痛的药物或其他疗法独立于每种手术方法且是术前准备措施。最后,对于对其他干预措施难治性疼痛的患者管理中涉及阿片类药物的使用。这种方法可以为绝大多数患者提供充分的缓解。我们发现癌症疼痛患者的吗啡成瘾风险在科学上没有充分依据。

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