Aguilar L, Martín M, Balcabao I P, Gómez-Lus M L, Dal-Ré R, Prieto J
Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.
Antimicrob Agents Chemother. 1997 Jun;41(6):1403-5. doi: 10.1128/AAC.41.6.1403.
The effects on Staphylococcus aureus viability and beta-lactamase activity of concentrations that simulated those in human serum after a combined dose of 875 mg of amoxicillin and 125 mg of clavulanic acid were studied in an in vitro pharmacodynamic model. Six hours of preexposure to concentrations of the amoxicillin-clavulanic acid combination that were higher than the amoxicillin-clavulanic acid MIC led to a reduction of the initial inoculum of >90% and to a significant decrease of beta-lactamase activity versus those of the control even from 6 h, when concentrations were subinhibitory. The postantibiotic effect and post-beta-lactamase inhibitor effect contributed to these results.
在体外药效学模型中,研究了联合使用875mg阿莫西林和125mg克拉维酸后模拟人血清中浓度对金黄色葡萄球菌活力和β-内酰胺酶活性的影响。预先暴露于高于阿莫西林-克拉维酸最低抑菌浓度(MIC)的阿莫西林-克拉维酸组合浓度6小时,导致初始接种量减少>90%,并且即使在浓度低于抑菌浓度时,从6小时起β-内酰胺酶活性相对于对照组也显著降低。抗生素后效应和β-内酰胺酶抑制剂后效应促成了这些结果。