McDonald P J, Craig W A, Kunin C M
J Infect Dis. 1977 Feb;135(2):217-23. doi: 10.1093/infdis/135.2.217.
Persistent suppression of bacterial growth by certain antibiotics was tested by periodic counts of viable organisms in a culture of Staphylococcus aureus that had been incubated in media containing drugs for limited periods of time and then removed by centrifugation. During short (2 hr) periods of exposure of test cultures to penicillin G, cephalothin, erythromycin, clindamycin, vancomycin, and tetracyline, effects on the growth of S. aureus were produced that persisted after removal of the drug for periods of 1.7-4.1 hr. A persistent antibiotic effect was not observed with gentamicin. The persistent effects of penicillin G and erythromycin were directly related to duration of exposure and concentration of drug, up to a point of maximal response. The maximal durations of bacterial suppression after exposure to penicillin G and erythromycin were approximately 2 and 5 hr, respectively. These effects were observed over a wide range of inocula.
通过定期计数金黄色葡萄球菌培养物中的活菌来测试某些抗生素对细菌生长的持续抑制作用，该培养物在含有药物的培养基中孵育有限时间后通过离心去除药物。在测试培养物短时间（2小时）暴露于青霉素G、头孢噻吩、红霉素、克林霉素、万古霉素和四环素期间，对金黄色葡萄球菌生长产生的影响在去除药物后持续1.7 - 4.1小时。未观察到庆大霉素有持续抗生素作用。青霉素G和红霉素的持续作用与暴露持续时间和药物浓度直接相关，直至达到最大反应点。暴露于青霉素G和红霉素后细菌抑制的最大持续时间分别约为2小时和5小时。在广泛的接种量范围内均观察到了这些效应。
