哥本哈根大鼠可移植性腺癌（R - 3327）的化学疗法。

Chemotherapy of the transplantable adenocarcinoma (R-3327) of the Copenhagen rat.

作者信息

Block N L, Camuzzi F, Denefrio J, Troner M, Claflin A, Stover B, Politano V A

出版信息

Oncology. 1977;34(3):110-3. doi: 10.1159/000225202.

Abstract

A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the results of this study and those of similar therapeutic application to the human tumor. We conclude that this animal model may prove to be a useful screening system for agents against human prostatic cancer.

摘要

包括左旋门冬酰胺酶、放线菌素-D、环己亚硝脲、羟基脲、5-氟尿嘧啶、顺铂、环磷酰胺、睾丸切除术、阿霉素和己烯雌酚在内的多种治疗药物已单独或联合应用于邓宁R-3327大鼠前列腺腺癌G亚系。我们发现这项研究的结果与针对人类肿瘤的类似治疗应用的结果之间存在相似之处。我们得出结论，这种动物模型可能被证明是一种用于筛选抗人类前列腺癌药物的有用系统。