González-Bosquet E, Martínez-Palones J M, González-Bosquet J, García Jiménez A, Xercavins J
Department of Gynecologic Surgery/Gynecologic Oncology, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, Spain.
Eur J Gynaecol Oncol. 1997;18(3):192-5.
To evaluate the clinical outcome of patients suffering from primary uterine sarcoma diagnosed and treated in our Hospital.
Department of Gynecologic Surgery/Gynecologic Oncology, Hospital Universitario Materno-Infantil Vall d'Hebron de Barcelona, Barcelona, Spain.
A retrospective review from 1967 to 1995 of clinical and pathological characteristics of 93 patients with primary uterine sarcoma was done. Patients were staged using the 1988 FIGO histological classification for uterine cancer. Clinical features, type of surgery, adjuvant therapy, recurrences, distant metastasis, and survival were recorded.
Our study included three main histologic types: 44 patients with leiomyosarcoma, 26 patients with endometrial stromal sarcoma, and 18 patients with mixed Müllerian sarcomas. The mean age for all patients was 54.8 years, and the most common symptom was vaginal bleeding. Other clinicopathological features were examined. Although surgery was the most frequent treatment, adjuvant therapies have been analyzed and discussed. The overall three-year survival rate was 67.9% and the overall five-year survival rate was 64.5%. We found statistical differences (p < 0.001) between the stage I survival rate and other stage survival rates.
Uterine sarcoma is an uncommon neoplasia diagnosed in the 6th decade of life. Leiomyosarcoma is the most frequent histologic type (47.3%). Stage I uterine sarcoma has a better prognosis than other stages.
评估在我院诊断和治疗的原发性子宫肉瘤患者的临床结局。
西班牙巴塞罗那瓦尔德希伯伦大学母婴医院妇科手术/妇科肿瘤学系。
对1967年至1995年期间93例原发性子宫肉瘤患者的临床和病理特征进行回顾性研究。采用1988年国际妇产科联盟（FIGO）子宫癌组织学分类对患者进行分期。记录临床特征、手术类型、辅助治疗、复发、远处转移和生存情况。
我们的研究包括三种主要组织学类型：44例平滑肌肉瘤患者、26例子宫内膜间质肉瘤患者和18例混合性苗勒管肉瘤患者。所有患者的平均年龄为54.8岁，最常见的症状是阴道出血。对其他临床病理特征进行了检查。虽然手术是最常用的治疗方法，但也对辅助治疗进行了分析和讨论。总体三年生存率为67.9%，总体五年生存率为64.5%。我们发现I期生存率与其他期生存率之间存在统计学差异（p<0.001）。
子宫肉瘤是一种在60岁左右诊断出的罕见肿瘤。平滑肌肉瘤是最常见的组织学类型（47.3%）。I期子宫肉瘤的预后比其他期更好。
