Kable M L, Heidmann S, Stuart K D
Seattle Biomedical Research Institute, WA 98109, USA.
Trends Biochem Sci. 1997 May;22(5):162-6. doi: 10.1016/s0968-0004(97)01041-4.
RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable of a full round of guide-RNA-directed editing.
动质体原生动物中的RNA编辑通过尿苷酸残基的精确插入和缺失来重塑线粒体前体mRNA的序列。这些序列变化由称为引导RNA的小反式作用RNA指导。最近，利用能够进行一轮完整的引导RNA指导编辑的体外系统，阐明了产生编辑后RNA的基本机制途径。
