Xin Z C, Choi Y D, Lee S H, Choi H K
Department of Urology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1997 Apr;38(2):91-5. doi: 10.3349/ymj.1997.38.2.91.
SS-cream is a topical agent for treating premature ejaculation (PE) which is made with extracts from 9 natural products. We evaluated the efficacy of SS-cream in the treatment of PE. An open pilot study was performed in 186 patients with PE. The mean ejaculatory latency from intromission to ejaculation was 1.5 minutes. Sixty-four of the 186 patients (34.4%) were combined with mild erectile dysfunction in whom penile rigidity was not sufficient to be satisfied in sexual activity. Patients were instructed to apply 0.1 gm. of SS-cream on the glans penis 1 hour before sexual contact and to wash out the cream before sexual intromission. Patients were asked to complete a report form including ejaculatory latency, the degree of satisfaction in the sexual lives of both themselves and their partners, and any adverse effects after each application. One hundred and sixty-six out of 186 patients (89.2%) reported they were satisfied with the application of the SS-cream and the mean ejaculatory latency was significantly prolonged to 10.89 +/- 5.60 minutes. The mean ejaculatory latency was 9.85 +/- 3.58 minutes in 52 out of 64 patients (81.2%) with mild erectile dysfunction. There was no significant difference in the changes of ejaculatory latencies between patients with pure PE and patients with mild erectile dysfunction. Twenty patients (10.8%) claimed to have no changes of ejaculatory latencies after the application of SS-cream. Adverse effects were noted in 11 patients (5.9%), which were mild local irritation symptoms in 7 patients, and delayed ejaculation of more than 30 minutes in 4 patients, the symptoms subsided spontaneously within 4 hours. These results indicate SS-cream is effective in the treatment of PE and also PE combined with mild erectile dysfunction with a few side effects. Further studies on the action mechanisms of SS-cream and a double blind placebo-controlled trial are needed.
SS霜是一种用于治疗早泄（PE）的外用制剂，由9种天然产物提取物制成。我们评估了SS霜治疗PE的疗效。对186例PE患者进行了一项开放性试点研究。从插入到射精的平均射精潜伏期为1.5分钟。186例患者中有64例（34.4%）合并轻度勃起功能障碍，其阴茎硬度不足以在性生活中达到满意状态。指导患者在性接触前1小时将0.1克SS霜涂抹于阴茎龟头，并在插入前洗净霜剂。要求患者填写一份报告表，包括射精潜伏期、自身及其伴侣性生活的满意度以及每次用药后的任何不良反应。186例患者中有166例（89.2%）报告对SS霜的应用感到满意，平均射精潜伏期显著延长至10.89±5.60分钟。64例轻度勃起功能障碍患者中有52例（81.2%）的平均射精潜伏期为9.85±3.58分钟。单纯PE患者和轻度勃起功能障碍患者射精潜伏期的变化无显著差异。20例患者（10.8%）声称使用SS霜后射精潜伏期无变化。11例患者（5.9%）出现不良反应，其中7例为轻度局部刺激症状，4例为射精延迟超过30分钟，症状在4小时内自行消退。这些结果表明SS霜治疗PE以及PE合并轻度勃起功能障碍有效，且副作用较少。需要对SS霜的作用机制进行进一步研究并开展双盲安慰剂对照试验。
