Fdez Espejo E, Gil E
Depto. de Fisiología Medica y Biofísica, Universidad de Sevilla, Seville, Spain.
Brain Res. 1997 May 2;755(2):351-5. doi: 10.1016/s0006-8993(97)00242-4.
The objective of this study was two-fold: (i) to analyze behavioral sensitization to haloperidol 2 weeks after single restraint stress, and (ii) to establish the effects of 8-OH-DPAT treatment prior to stress on sensitized behavioral responses. Overall behavior was analyzed and not only catalepsy, but also sedation (immobility), grooming, exploration and vacuous chewing movements were evaluated. Results indicated that single restraint stress induced a long-lasting sensitization of acute vacuous chewing movements induced by haloperidol (0.25, 0.5 mg/kg i.p.). Interestingly, this behavioral sensitization was prevented by 8-OH-DPAT (0.35 mg/kg s.c.) prior to stress. Finally, haloperidol-induced sedation was not disrupted by either restraint stress or 8-OH-DPAT treatment.
（i）分析单次束缚应激2周后对氟哌啶醇的行为敏化作用，以及（ii）确定应激前8-OH-DPAT治疗对敏化行为反应的影响。对整体行为进行了分析，不仅评估了僵住症，还评估了镇静（不动）、梳理、探索和空嚼运动。结果表明，单次束缚应激诱导了氟哌啶醇（0.25、0.5毫克/千克腹腔注射）引起的急性空嚼运动的持久敏化。有趣的是，这种行为敏化在应激前被8-OH-DPAT（0.35毫克/千克皮下注射）阻止。最后，氟哌啶醇诱导的镇静不受束缚应激或8-OH-DPAT治疗的干扰。
