Moodley D, Coovadia H M, Bobat R A, Gouws E, Munsamy Y
Department of Paediatrics and Child Health, University of Natal, South Africa.
Ann Trop Paediatr. 1997 Mar;17(1):83-7. doi: 10.1080/02724936.1997.11747868.
In a cohort of 56 children born to HIV-seropositive African women, 19 met the criteria for HIV-infected children and 37 remained antibody-negative at 18 months of age. Blood samples taken at birth and 3-monthly until 18 months of age were processed and analysed by laser nephelometry for serum immunoglobulin (IgG, IgA and IgM) levels. In the infected group of children. higher levels of IgG were observed during their 1st 18 months of life reaching statistical significance at 3, 6, 15 and 18 months. Higher levels of IgA at 3 months and at 15 and 18 months, and higher levels of IgM at 3 months and 18 months later were statistically significant. All four infected children who died before the age of 6 months showed signs of hypergammaglobulinaemia (IgG and IgA) by 3 months of age. In this study the earliest and most common immunological abnormality was hypergammaglobulinaemia and infected infants with higher morbidity and mortality had more evident immunoglobulin abnormalities than infected children who survived. However, the immunological abnormalities in this small cohort did not precede the onset of severe symptoms and cannot therefore be used to predict clinical outcome.
在一组由感染艾滋病毒的非洲女性所生的56名儿童中，19名符合感染艾滋病毒儿童的标准，37名在18个月大时抗体仍为阴性。采集出生时及3个月一次直至18个月大的血样，通过激光散射比浊法检测血清免疫球蛋白（IgG、IgA和IgM）水平并进行分析。在受感染儿童组中，观察到其出生后的前18个月内IgG水平较高，在3个月、6个月、15个月和18个月时具有统计学意义。3个月、15个月和18个月时IgA水平较高，3个月和18个月时IgM水平较高，均具有统计学意义。所有4名在6个月前死亡的受感染儿童在3个月大时均表现出高丙种球蛋白血症（IgG和IgA）迹象。在本研究中，最早且最常见的免疫异常是高丙种球蛋白血症，发病和死亡率较高的受感染婴儿比存活的受感染儿童有更明显的免疫球蛋白异常。然而，这一小组中的免疫异常在严重症状出现之前并未出现，因此不能用于预测临床结果。
