肿瘤坏死因子-α可增强博来霉素电化学疗法对小鼠SA-1肿瘤的抗肿瘤效果。

Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alpha on SA-1 tumors in mice.

作者信息

Sersa G, Cemazar M, Menart V, Gaberc-Porekar V, Miklavcic D

机构信息

Department of Tumor Biology, Institute of Oncology, Zaloska, Ljubljana, Slovenia.

出版信息

Cancer Lett. 1997 Jun 3;116(1):85-92. doi: 10.1016/s0304-3835(97)00170-5.

DOI:10.1016/s0304-3835(97)00170-5

PMID:9177462

Abstract

With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha treatment might be immunomodulatory, augmenting the anti-tumor activity of electrochemotherapy, and possibly adding a systemic component to the localized electrochemotherapy treatment.

摘要

为提高电化学疗法的抗肿瘤效果，对小鼠肿瘤进行了肿瘤坏死因子-α（TNF-α）辅助免疫治疗测试。在使用次优剂量博来霉素（BLM）进行电化学疗法的同时，瘤内或瘤周注射TNF-α，观察到SA-1肿瘤的抗肿瘤效果增强。抗肿瘤效果增强既不是由于肿瘤暴露于电脉冲而增强了TNF-α的抗肿瘤效果，也不是由于与BLM相互作用所致。因此，辅助TNF-α治疗的作用可能是免疫调节作用，增强了电化学疗法的抗肿瘤活性，并可能为局部电化学疗法增加了全身作用成分。