Gold P W, Weingartner H, Ballenger J C, Goodwin F K, Post R M
Lancet. 1979 Nov 10;2(8150):992-4. doi: 10.1016/s0140-6736(79)92563-7.
DDAVP (1-desamino-8-d-arginine vasopressin), a synthetic analogue of vasopressin with prolonged half-life and high antidiuretic and low pressor activity, was given in a double-blind placebo-controlled trial to four patients with major affective illness. Three of four patients showed highly significant and consistent improvements in tests designed to measure the formation, encoding, and organisation of long-term trace events in memory. Two patients also showed a significant but less consistent amelioration of other depressive symptoms during DDAVP treatment. These findings implicate central vasopressin function in the processing of information and possibly other aspects of affective illness.
去氨加压素（1-去氨基-8-D-精氨酸加压素）是一种加压素的合成类似物，半衰期延长，具有高抗利尿活性和低升压活性。在一项双盲安慰剂对照试验中，对4例重症情感障碍患者使用了去氨加压素。在旨在测量记忆中长期痕迹事件的形成、编码和组织的测试中，4例患者中有3例显示出高度显著且一致的改善。2例患者在去氨加压素治疗期间，其他抑郁症状也有显著但不太一致的改善。这些发现表明中枢加压素功能在信息处理以及情感障碍的其他方面可能发挥作用。
