Stephenson K A, Lean I J, Hyde M L, Curtis M A, Garvin J K, Lowe L B
Department to Animal Science, University of Sydney, Camden New South Wales, Australia.
J Dairy Sci. 1997 May;80(5):830-7. doi: 10.3168/jds.S0022-0302(97)76004-1.
The effects of monensin on plasma concentrations and changes in plasma concentrations of energy metabolites and minerals over time were investigated using 24 multiparous Holstein cows. Cows were paired according to farm, predicted date of calving, and body condition score and were randomly allocated to two groups. Treated cows were given a ruminal bolus containing 32 g of monensin at 50 +/- 7 d before predicted calving. Treated cows had lower plasma concentrations of glucose, free fatty acid (FFA), and beta-hydroxybutyrate (BHBA) than did control cows before calving, indicating that monensin influenced energy metabolism. However, no significant differences in plasma concentrations of glucose, FFA, and BHBA were found between groups after calving. Plasma BHBA concentrations increased more before calving in control cows, and plasma FFA and urea concentrations increased significantly before calving in all cows. No significant differences in body weight, plasma concentrations of urea, or whole blood concentrations of glutathione peroxidase were detected between groups before or after calving. Plasma ceruloplasmin activity did not differ between groups before calving, but was significantly higher in treated cows after calving. Plasma concentrations of Ca did not significantly differ between groups before or after calving. Monensin altered both energy and mineral metabolism and has the potential to improve the health and production of dairy cows.
使用24头经产荷斯坦奶牛研究了莫能菌素对血浆浓度以及能量代谢物和矿物质血浆浓度随时间变化的影响。奶牛根据农场、预测产犊日期和体况评分进行配对，并随机分为两组。在预测产犊前50±7天，给处理组奶牛投喂含有32克莫能菌素的瘤胃大丸剂。产犊前，处理组奶牛的葡萄糖、游离脂肪酸（FFA）和β-羟基丁酸（BHBA）的血浆浓度低于对照组奶牛，表明莫能菌素影响能量代谢。然而，产犊后两组之间的葡萄糖、FFA和BHBA的血浆浓度没有显著差异。对照组奶牛产犊前血浆BHBA浓度升高更多，所有奶牛产犊前血浆FFA和尿素浓度显著升高。产犊前后两组之间的体重、血浆尿素浓度或全血谷胱甘肽过氧化物酶浓度均未检测到显著差异。产犊前两组之间的血浆铜蓝蛋白活性没有差异，但产犊后处理组奶牛的血浆铜蓝蛋白活性显著更高。产犊前后两组之间的血浆钙浓度没有显著差异。莫能菌素改变了能量和矿物质代谢，有改善奶牛健康和生产性能的潜力。
