呋喃硫胺-甲硝唑联合制剂治疗阿米巴病和贾第虫病的疗效。

Efficacy of a combined diloxanide furoate-metronidazole preparation in the treatment of amoebiasis and giardiasis.

作者信息

Qureshi H, Ali A, Baqai R, Ahmed W

机构信息

Pakistan Medical Research Council Research Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

出版信息

J Int Med Res. 1997 May-Jun;25(3):167-70. doi: 10.1177/030006059702500307.

DOI:10.1177/030006059702500307

PMID:9178149

Abstract

A combined formulation of diloxanide furoate and metronidazole was used to treat amoebiasis and giardiasis (cysts and vegetative forms) in 54 patients. Of these 34 patients had amoebiasis, 19 had giardiasis and one had mixed infection. Each patient took one tablet (containing 500 mg diloxanide furoate and 400 mg metronidazole), three times daily for 5 days, and the response to therapy was checked by clinical examination and by examination of fresh stools on days 3, 5 and 10. Abdominal pain was completely relieved in 91% and 84% of patients with amoebiasis and giardiasis, respectively, while parasitic clearance was 100% in both groups. Tolerance to the drug was adequate.

摘要

采用双碘喹啉酯和甲硝唑联合制剂治疗54例阿米巴病和贾第虫病（囊肿和滋养体）患者。其中34例患有阿米巴病，19例患有贾第虫病，1例为混合感染。每位患者每日服用1片（含500毫克双碘喹啉酯和400毫克甲硝唑），每日3次，共服用5天，并在第3、5和10天通过临床检查和新鲜粪便检查来检查治疗反应。阿米巴病和贾第虫病患者中分别有91%和84%的腹痛完全缓解，而两组的寄生虫清除率均为100%。药物耐受性良好。