Aires S T, Paiva D S, Santos L V, Paiva D N, Rocco P R, Zin W A
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Respir Physiol. 1997 Apr;108(1):73-7. doi: 10.1016/s0034-5687(97)02528-0.
This study was performed to evaluate the role of diethylcarbamazine (DEC), the drug of choice for treating Lymphatic Filariasis and Tropical Pulmonary Eosinophilia, on respiratory mechanics of higid rats. Thus, during 30 days two groups of six rats each received intraperitoneally either isotonic saline solution, or 12 mg/kg per day of DEC. Thereafter, they were sedated, anesthetized, paralysed and mechanical ventilation followed. After airway occlusion at end inspiration, respiratory system, pulmonary and chest wall resistive pressures (delta P1,rs, delta P1,L, and delta P1,w, respectively) and viscoelastic/inhomogeneous pressures (delta P2,rs, delta P2,L and delta P2,w, respectively) were determined in each group. Total delta pressures (delta Ptot) were calculated as the sum of delta P1 and delta P2, yielding the values of delta Ptot,rs, delta Ptot,L, and delta Ptot,w, respectively. Respiratory system, lung and chest wall static (Est,rs, Est,L, and Est,w, respectively) and dynamic elastances (Edyn,rs, Edyn,L, and Edyn,w, respectively), and the corresponding delta elastances (calculated as Edyn-Est) were also obtained. DEC therapy significantly decreased delta Ptot,rs, delta P tot,L, delta P2,rs, delta P2,L, Est,ts, Est,L, delta Ers and delta EL, in relation to the respective control values. It can be concluded that DEC decreases respiratory system impedance, being potentially useful for allowing airway dilation at the lung periphery.
本研究旨在评估乙胺嗪（DEC）对高气道阻力大鼠呼吸力学的作用，DEC是治疗淋巴丝虫病和热带肺嗜酸性粒细胞增多症的首选药物。因此，在30天内，两组各6只大鼠分别腹腔注射等渗盐溶液或每天12mg/kg的DEC。此后，对它们进行镇静、麻醉、麻痹并进行机械通气。在吸气末气道阻塞后，测定每组的呼吸系统、肺和胸壁的阻力压力（分别为δP1,rs、δP1,L和δP1,w）以及粘弹性/非均匀压力（分别为δP2,rs、δP2,L和δP2,w）。总δ压力（δPtot）计算为δP1和δP2之和，分别得出δPtot,rs、δPtot,L和δPtot,w的值。还获得了呼吸系统、肺和胸壁的静态弹性（分别为Est,rs、Est,L和Est,w）和动态弹性（分别为Edyn,rs、Edyn,L和Edyn,w），以及相应的δ弹性（计算为Edyn-Est）。与各自的对照值相比，DEC治疗显著降低了δPtot,rs、δPtot,L、δP2,rs、δP2,L、Est,ts、Est,L、δErs和δEL。可以得出结论，DEC降低了呼吸系统阻抗，可能有助于肺周边气道扩张。
