Goodhill G J, Bates K R, Montague P R
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Proc Biol Sci. 1997 May 22;264(1382):649-55. doi: 10.1098/rspb.1997.0092.
Cortical maps often contain global spatial structure: however, theoretical accounts for their development have generally concentrated on reproducing only local structure. We show that the elastic net model of cortical map formation can closely approximate the global structure of the ocular dominance column map observed in macaque primary visual cortex. A key component is the assumption of spatially non-uniform and anisotropic correlations in the retina. This work shows how genetic and epigenetic effects could combine to establish characteristic global structure in cortical maps.
然而,关于其发育的理论解释通常只专注于重现局部结构。我们表明,皮层图谱形成的弹性网络模型能够紧密近似猕猴初级视觉皮层中观察到的眼优势柱图谱的全局结构。一个关键因素是视网膜中存在空间非均匀和各向异性相关性的假设。这项工作展示了遗传和表观遗传效应如何结合起来在皮层图谱中建立特征性的全局结构。