Brehar-Cioflec D, Vajda A, Negrea D A, Străin R, Tudose N, Sporea I, Moldovan R, Chidioşan C, Chirileanu O, Gaiţă-Criveanu D
Medical Center for Health Management Services, Timişoara.
Rom J Virol. 1995 Jul-Dec;46(3-4):107-13.
A number of 112 patients hospitalized for chronic hepatitis and liver cirrhosis were investigated. According to the results of the pathomorphological examinations of liver biopsies, 29 (25.8%) were cases of persistent chronic hepatitis (PCH), 39 (34.8%) cases of active chronic hepatitis (ACH), and 44 (39.2%) cases of liver cirrhosis. The prevalence of the female sex was observed in PCH (61.6%) and ACH (64.7%) cases, whereas in liver cirrhosis the sex distribution was more balanced (53.3% patients were males). The patients' mean age ranged from 34 to 38 years in PCH cases, from 44 to 46 years in ACH cases and from 50 to 57 years in liver cirrhosis. The postviral cirrhosis was three times more frequent in the female sex (77%), while the alcoholic and mixed cirrhoses (of an associated alcoholic and viral etiology) were prevalent in males (63.2%, respectively 72.2%). Serological tests for detection of the serological markers of hepatitis viruses B (HBV), C (HCV) and Delta (HDV) were performed for the purpose of studying the correlations between the pathomorphological findings and the viral markers. Among the 39 patients with ACH, HBV markers were detected in 13 cases (33.3%), anti-HCV antibodies in 10 (25.6%), and associated HBV-HCV, respectively HBV-HDV infections in 9 (23%) cases (6, respectively 3 patients). In the remaining 7 cases (17.9%) of ACH, there were no serological markers in the three hepatitis viruses. Of the 29 patients with PCH, 17 cases (58.6%) displayed HBV markers, 4 (13.7%) anti-HCV antibodies, in one patient (3.4%) an associated HBV-HCV infection was present, and in 7 patients (24.1%) markers of none of the three hepatitis viruses could be identified. Of the 44 patients with liver cirrhosis, HBV markers were detected in 17 cases (38.6%), anti-HCV antibodies in 9 (20.4%) and associated HBV-HCV and, respectively, HBV-HDV infections in 11 cases (25%) (9, respectively 2 cases). In 7 (15.9%) of the 44 patients with cirrhosis, markers of none of the three hepatitis viruses could be identified.
对112例因慢性肝炎和肝硬化住院的患者进行了调查。根据肝活检的病理形态学检查结果，持续性慢性肝炎（PCH）29例（25.8%），活动性慢性肝炎（ACH）39例（34.8%），肝硬化44例（39.2%）。PCH（61.6%）和ACH（64.7%）病例中女性患病率较高，而肝硬化患者的性别分布更为均衡（53.3%为男性）。PCH患者的平均年龄在34至38岁之间，ACH患者在44至46岁之间，肝硬化患者在50至57岁之间。女性的病毒后肝硬化发生率是男性的三倍（77%），而酒精性和混合性肝硬化（酒精和病毒相关病因）在男性中更为常见（分别为63.2%和72.2%）。为了研究病理形态学结果与病毒标志物之间的相关性，对乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和丁型肝炎病毒（HDV）的血清学标志物进行了检测。在39例ACH患者中，1 . 3例（33.3%）检测到HBV标志物，10例（25.6%）检测到抗HCV抗体，9例（23%）检测到HBV-HCV合并感染以及HBV-HDV合并感染（分别为6例和3例）。在其余7例（17.9%）ACH患者中，三种肝炎病毒均无血清学标志物。在29例PCH患者中，17例（58.6%）显示HBV标志物，4例（13.7%）显示抗HCV抗体，1例（3.4%）存在HBV-HCV合并感染，7例（24.1%）未检测到三种肝炎病毒中的任何一种标志物。在44例肝硬化患者中，17例（38.6%）检测到HBV标志物，9例（20.4%）检测到抗HCV抗体，11例（25%）检测到HBV-HCV合并感染以及HBV-HDV合并感染（分别为9例和2例）。在44例肝硬化患者中的7例（15.9%）中，未检测到三种肝炎病毒中的任何一种标志物。
