Sarin S K, Guptan R C, Banerjee K, Khandekar P
Department of Gastroenterology, G.B. Pant Hospital, New Delhi.
J Assoc Physicians India. 1996 Apr;44(4):243-5.
To investigate the prevalence and profile of chronic liver disease due to hepatitis B (HBV) and C (HCV) infection in patients with non-alcoholic chronic liver disease in North India, 148 biopsy proven patients (73 with a history of transfusion and 75 non-transfused) were studied. Detection of hepatitis B included HBsAg, AntiHBc, and HBV DNA testing. Presence of HCV infection was investigated by EIA using second generation tests and confirmed by RIBA III and HCV RNA testing. Eighty three (56.1%) patients had cirrhosis related to hepatitis B, 13 (15.7%) of them had precore (HBeAg -ve, HBVDNA +ve) and 11 (13%) had surface (HBsAg-ve, IgM antiHBc-ve, HBVDNA +ve) mutation. Antibodies to HCV were found in 16 (10.8%) patients. Dual infection with HBV and HCV was seen in 20 (13.5%) patients. Twenty nine (19.5%) patients, had cryptogenic cirrhosis as none of the markers for HBV or HCV infection was positive. In conclusion, our results demonstrate that HBV was the most prevalent viral infection associated with chronic liver disease patients in North India. Prevalence of HCV infection was low. Studies to detect HBV mutants and other viruses should be done in patients with suspected cryptogenic cirrhosis of the liver.
为调查印度北部非酒精性慢性肝病患者中乙型肝炎（HBV）和丙型肝炎（HCV）感染所致慢性肝病的患病率及特征，对148例经活检证实的患者（73例有输血史，75例无输血史）进行了研究。乙型肝炎检测包括HBsAg、抗HBc和HBV DNA检测。采用第二代酶免疫分析法（EIA）检测HCV感染情况，并通过重组免疫印迹法（RIBA）III和HCV RNA检测进行确认。83例（56.1%）患者患有与乙型肝炎相关的肝硬化，其中13例（15.7%）有前C区变异（HBeAg阴性，HBV DNA阳性），11例（13%）有表面区变异（HBsAg阴性，IgM抗HBc阴性，HBV DNA阳性）。16例（10.8%）患者检测到抗HCV抗体。20例（13.5%）患者同时感染HBV和HCV。29例（19.5%）患者患有隐源性肝硬化，因为HBV或HCV感染的标志物均为阴性。总之，我们的结果表明，HBV是印度北部与慢性肝病患者相关的最常见病毒感染。HCV感染患病率较低。对于疑似隐源性肝硬化患者，应开展检测HBV变异体和其他病毒的研究。
