Faden H, Duffy L, Wasielewski R, Wolf J, Krystofik D, Tung Y
Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, USA.
J Infect Dis. 1997 Jun;175(6):1440-5. doi: 10.1086/516477.
Streptococcus pneumoniae, nontypeable Haemophilus influenzae, and Moraxella catarrhalis are the predominant bacteria associated with otitis media. A cohort of 306 infants was followed from birth through 12 months to determine frequency and duration of colonization and risk of acute otitis media (AOM) and otitis media with effusion (OME). M. catarrhalis was the most common bacterium isolated. Infants colonized at < or = 3 months of age were at increased risk of AOM and OME. Early colonization with M. catarrhalis revealed the greatest risk (relative risk [RR] = 1.24), especially for OME (RR = 1.57). There was a strong relationship between the frequency of colonization and OM (r = .37, P < .001,) for each pathogen. Although S. pneumoniae, nontypeable H. influenzae, and M. catarrhalis are part of the normal nasopharyngeal flora during infancy, an increased rate of colonization may identify a subpopulation of children that is at increased risk of OM.
肺炎链球菌、不可分型流感嗜血杆菌和卡他莫拉菌是与中耳炎相关的主要细菌。对306名婴儿进行了从出生到12个月的随访，以确定定植的频率和持续时间以及急性中耳炎（AOM）和中耳积液（OME）的风险。卡他莫拉菌是分离出的最常见细菌。3个月及以下龄婴儿定植后发生AOM和OME的风险增加。早期定植卡他莫拉菌显示出最大风险（相对风险[RR]=1.24），尤其是对于OME（RR=1.57）。每种病原体的定植频率与中耳炎之间存在很强的相关性（r=0.37，P<0.001）。虽然肺炎链球菌、不可分型流感嗜血杆菌和卡他莫拉菌是婴儿期正常鼻咽菌群的一部分，但定植率增加可能会识别出患中耳炎风险增加的儿童亚群。
